Assessment of Quality of Life with the Multiple System Atrophy Health-Related Quality of Life Scale
Identifieur interne : 001206 ( Main/Exploration ); précédent : 001205; suivant : 001207Assessment of Quality of Life with the Multiple System Atrophy Health-Related Quality of Life Scale
Auteurs : Wassilios G. Meissner [France] ; Alexandra Foubert-Samier [France] ; Sandrine Dupouy [France] ; Angélique Gerdelat-Mas [France] ; Rachel Debs [France] ; Fabienne Marquant [France] ; Valérie Cochen De Cock [France] ; Olivier Rascol [France] ; François Tison [France] ; Anne Pavy-Le Traon [France]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Background: Multiple system atrophy (MSA) has considerable effect on health-related quality of life (Hr-QoL). The aim of this study was to prospectively evaluate Hr-QoL by using the MSA health-related Quality of Life (MSA-QoL) scale. Methods: Evaluation of 100 patients at baseline and after a mean follow-up of 11.5 months was performed. Assessment was made of potential associations with established markers of disease progression. Calculation was performed of sample-size estimates for various effect sizes. Results: MSA-QoL scale scores were less responsive to change than Unified MSA Rating Scale (UMSARS) scores. Responsiveness was largely improved and reasonable sample-size estimates were obtained when limiting the analysis to items with significant change over time. Conclusions: The UMSARS remains the "gold standard" for disease-modifying/neuroprotection trials. An MSA-QoL Change Scale, based on the most responsive items, may become a valuable tool.
Affiliations:
- France
- Aquitaine, Midi-Pyrénées
- Bordeaux, Toulouse
- Université Toulouse III - Paul Sabatier, Université de Bordeaux, Université de Toulouse
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first="Wassilios G." last="Meissner">Wassilios G. Meissner</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Reference Atrophie Multisystématisée, CHU de Bordeaux</s1><s2>Pessac</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>CHU de Bordeaux</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Service de Neurologie, CHU de Bordeaux</s1><s2>Pessac</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>CHU de Bordeaux</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Université de Bordeaux, Institut des Maladies Neurodégénèratives, UMR 5293</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Aquitaine</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>CNRS, Institut des Maladies Neurodégénératives, UMR 5293</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Foubert Samier, Alexandra" sort="Foubert Samier, Alexandra" uniqKey="Foubert Samier A" first="Alexandra" last="Foubert-Samier">Alexandra Foubert-Samier</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Reference Atrophie Multisystématisée, CHU de Bordeaux</s1><s2>Pessac</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>CHU de Bordeaux</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Service de Neurologie, CHU de Bordeaux</s1><s2>Pessac</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>CHU de Bordeaux</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Dupouy, Sandrine" sort="Dupouy, Sandrine" uniqKey="Dupouy S" first="Sandrine" last="Dupouy">Sandrine Dupouy</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Reference Atrophie Multisystématisée, CHU de Bordeaux</s1><s2>Pessac</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>CHU de Bordeaux</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Service de Neurologie, CHU de Bordeaux</s1><s2>Pessac</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>CHU de Bordeaux</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Gerdelat Mas, Angelique" sort="Gerdelat Mas, Angelique" uniqKey="Gerdelat Mas A" first="Angélique" last="Gerdelat-Mas">Angélique Gerdelat-Mas</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre de Reference Atrophie Multisystématisée, CHU de Toulouse</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Debs, Rachel" sort="Debs, Rachel" uniqKey="Debs R" first="Rachel" last="Debs">Rachel Debs</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre de Reference Atrophie Multisystématisée, CHU de Toulouse</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Marquant, Fabienne" sort="Marquant, Fabienne" uniqKey="Marquant F" first="Fabienne" last="Marquant">Fabienne Marquant</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>CHU de Bordeaux, Unité de Soutien Méthodologique à la Recherche Clinique (USMR)</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Cochen De Cock, Valerie" sort="Cochen De Cock, Valerie" uniqKey="Cochen De Cock V" first="Valérie" last="Cochen De Cock">Valérie Cochen De Cock</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre de Reference Atrophie Multisystématisée, CHU de Toulouse</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre de Reference Atrophie Multisystématisée, CHU de Toulouse</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Toulouse</settlement></placeName><placeName><settlement type="city">Toulouse</settlement><region type="region" nuts="2">Midi-Pyrénées</region></placeName><orgName type="university" n="3">Université Toulouse III - Paul Sabatier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Toulouse</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Départements de Pharmacologie Clinique et Neurosciences, INSERM CIC9302, CHU de Toulouse</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Toulouse</settlement></placeName><placeName><settlement type="city">Toulouse</settlement><region type="region" nuts="2">Midi-Pyrénées</region></placeName><orgName type="university" n="3">Université Toulouse III - Paul Sabatier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Toulouse</orgName></affiliation></author><author><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Reference Atrophie Multisystématisée, CHU de Bordeaux</s1><s2>Pessac</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>CHU de Bordeaux</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Service de Neurologie, CHU de Bordeaux</s1><s2>Pessac</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>CHU de Bordeaux</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Université de Bordeaux, Institut des Maladies Neurodégénèratives, UMR 5293</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Aquitaine</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>CNRS, Institut des Maladies Neurodégénératives, UMR 5293</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Pavy Le Traon, Anne" sort="Pavy Le Traon, Anne" uniqKey="Pavy Le Traon A" first="Anne" last="Pavy-Le Traon">Anne Pavy-Le Traon</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre de Reference Atrophie Multisystématisée, CHU de Toulouse</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Toulouse</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Multiple system atrophy</term><term>Nervous system diseases</term><term>Parkinsonism</term><term>Quality of life</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Atrophie multisystématisée</term><term>Parkinsonisme</term><term>Pathologie du système nerveux</term><term>Qualité de vie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Multiple system atrophy (MSA) has considerable effect on health-related quality of life (Hr-QoL). The aim of this study was to prospectively evaluate Hr-QoL by using the MSA health-related Quality of Life (MSA-QoL) scale. Methods: Evaluation of 100 patients at baseline and after a mean follow-up of 11.5 months was performed. Assessment was made of potential associations with established markers of disease progression. Calculation was performed of sample-size estimates for various effect sizes. Results: MSA-QoL scale scores were less responsive to change than Unified MSA Rating Scale (UMSARS) scores. Responsiveness was largely improved and reasonable sample-size estimates were obtained when limiting the analysis to items with significant change over time. Conclusions: The UMSARS remains the "gold standard" for disease-modifying/neuroprotection trials. An MSA-QoL Change Scale, based on the most responsive items, may become a valuable tool.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Midi-Pyrénées</li></region><settlement><li>Bordeaux</li><li>Toulouse</li></settlement><orgName><li>Université Toulouse III - Paul Sabatier</li><li>Université de Bordeaux</li><li>Université de Toulouse</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G." last="Meissner">Wassilios G. Meissner</name></noRegion><name sortKey="Cochen De Cock, Valerie" sort="Cochen De Cock, Valerie" uniqKey="Cochen De Cock V" first="Valérie" last="Cochen De Cock">Valérie Cochen De Cock</name><name sortKey="Debs, Rachel" sort="Debs, Rachel" uniqKey="Debs R" first="Rachel" last="Debs">Rachel Debs</name><name sortKey="Dupouy, Sandrine" sort="Dupouy, Sandrine" uniqKey="Dupouy S" first="Sandrine" last="Dupouy">Sandrine Dupouy</name><name sortKey="Dupouy, Sandrine" sort="Dupouy, Sandrine" uniqKey="Dupouy S" first="Sandrine" last="Dupouy">Sandrine Dupouy</name><name sortKey="Foubert Samier, Alexandra" sort="Foubert Samier, Alexandra" uniqKey="Foubert Samier A" first="Alexandra" last="Foubert-Samier">Alexandra Foubert-Samier</name><name sortKey="Foubert Samier, Alexandra" sort="Foubert Samier, Alexandra" uniqKey="Foubert Samier A" first="Alexandra" last="Foubert-Samier">Alexandra Foubert-Samier</name><name sortKey="Gerdelat Mas, Angelique" sort="Gerdelat Mas, Angelique" uniqKey="Gerdelat Mas A" first="Angélique" last="Gerdelat-Mas">Angélique Gerdelat-Mas</name><name sortKey="Marquant, Fabienne" sort="Marquant, Fabienne" uniqKey="Marquant F" first="Fabienne" last="Marquant">Fabienne Marquant</name><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G." last="Meissner">Wassilios G. Meissner</name><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G." last="Meissner">Wassilios G. Meissner</name><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G." last="Meissner">Wassilios G. Meissner</name><name sortKey="Pavy Le Traon, Anne" sort="Pavy Le Traon, Anne" uniqKey="Pavy Le Traon A" first="Anne" last="Pavy-Le Traon">Anne Pavy-Le Traon</name><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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